Recurrence Factors in Cervical Precancerous Lesions

Wed, 29 Apr 2026 00:00:00 +0700

Background: Recurrent cervical pre-cancerous lesions remain a major clinical challenge in preventing progression to invasive cancer and achieving long-term remission. Persistent infection with high-risk human papillomavirus (HPV), particularly subtype 16, is strongly associated with recurrence, especially in women under 40 years of age.

Method: This narrative review analyzed recent literature focusing on the main determinants of recurrence after treatment of cervical pre-cancerous lesions, including viral, surgical, and immunological factors.

Result: The findings showed that incomplete surgical excision significantly increased the risk of recurrence. The type of surgical procedure also influenced outcomes, with cold knife and laser conization associated with lower recurrence rates than LLETZ. Post-treatment HPV vaccination was found to reduce recurrence by enhancing immunity against re-infection.

Implication: These findings highlight the importance of individualized treatment selection, complete lesion excision, and the use of HPV vaccination as part of a comprehensive strategy to minimize recurrence and improve long-term outcomes.
Novelty: This review provides an integrated overview of viral, surgical, and immunological factors influencing cervical lesion recurrence, emphasizing the importance of combining optimal surgical technique with preventive immunization.

Apakah Edukasi dengan Video Animasi Efektif terhadap Pengetahuan Remaja mengenai Perkawinan Anak?

Tania Ghifari Komara, Yulinda Yulinda, Desi Hidayanti, Kurniaty Ulfah — Wed, 29 Apr 2026 00:00:00 +0700

Background: This study aims to examine the effectiveness of animated video education on adolescents' knowledge about child marriage in Rancakasumba Village, Bandung Regency, Indonesia.

Method: The study used a quantitative approach with a quasi-experimental, non-randomized control group pretest-posttest design. Statistical analysis employed Mann-Whitney test for age distribution, Fisher's Exact Test for gender distribution, Chi-Square test for educational background, and Marginal Homogeneity test for pre-post intervention comparisons. The study population was adolescents in Rancakasumba Village, Bandung Regency, with a sample of 60 respondents divided into an experimental group (animated video) and a control group (leaflet). The research instrument was a structured questionnaire containing 29 questions that had been validated with a Cronbach's Alpha reliability value of 0.936. The animated video was developed collaboratively with health promotion students and validated by multimedia experts, while the leaflet contained equivalent educational content for the control group.

Result: The study showed that the animated video was more effective than the leaflet in increasing adolescents' knowledge about child marriage. The experimental group experienced an increase in knowledge, from 36.7% to 90% (p-value 0.001), while the control group only increased from 20% to 26.7% (p-value 0.025). Comparison between groups after the intervention showed a significant difference with a p-value of 0.028.

Implication: Healthcare professionals and policymakers should integrate animated video technology into routine reproductive health education programs to achieve optimal outcomes in preventing child marriage.

Novelty: This study comprehensively analyzes the effectiveness of animated videos using a quasi-experimental design that controls for confounding variables within the specific geographic and sociocultural context.

Griya Widya: Journal of Sexual and Reproductive Health

Recurrence Factors in Cervical Precancerous Lesions

Apakah Edukasi dengan Video Animasi Efektif terhadap Pengetahuan Remaja mengenai Perkawinan Anak?