https://journal.nurscienceinstitute.id/index.php/griyawidya <p style="text-align: justify;"><strong data-start="198" data-end="213">Griya Widya: Journal of Sexual and Reproductive Health</strong> [ISSN <strong><a href="https://issn.brin.go.id/terbit/detail/20211231401045151" target="_blank" rel="noopener">2809-6797</a></strong>] is a peer-reviewed journal committed to advancing knowledge in the field of sexual and reproductive health for both women and men. The journal serves as an authoritative platform for disseminating significant scientific information related to sexual and reproductive health care. It welcomes original research articles covering a wide range of topics, including family planning and contraception, adolescent sexual and reproductive health, sexuality education, sexually transmitted infections, and other relevant issues. Griya Widya aims to contribute meaningful insights and evidence to healthcare professionals and society, highlighting the intersection between sexual and reproductive health and individual rights. The journal promotes a multidisciplinary perspective and encourages studies that explore these issues in diverse social and cultural contexts. The journal accepts unpublished manuscripts written in either <strong>English</strong> or <strong>Bahasa</strong> <strong>Indonesia</strong>.</p> Nur Science Institute and Perkumpulan Keluarga Berencana Indonesia (PKBI) Semarang en-US Griya Widya: Journal of Sexual and Reproductive Health 2809-6797 <p style="text-align: justify;">Authors who publish with this journal agree to the following terms:</p> <p style="text-align: justify;">The author(s) retain copyright and grant the journal the right of first publication with the work simultaneously licensed under a <a href="https://creativecommons.org/licenses/by-sa/4.0/">CC BY-SA 4.0</a> license that allows others to remix, adapt, and build upon the work even for commercial purposes, as long as they credit the author(s) and license their new creations under the identical terms.</p> <p style="text-align: left;">License details: <a href="https://creativecommons.org/licenses/by-sa/4.0/">https://creativecommons.org/licenses/by-sa/4.0/</a></p> https://journal.nurscienceinstitute.id/index.php/griyawidya/article/view/1886 <p><strong>Background: </strong>This narrative review examines how melatonin enhances reproductive health functions. Melatonin has established itself as a multifaceted neurohormone with pivotal roles in female reproductive health. Through its potent antioxidant properties, melatonin protects oocytes and orchestrates hormonal regulation and ovarian function, with melatonin receptors strategically located in key reproductive tissues, including ovarian granulosa and luteal cells.</p> <p><strong>Method: </strong>This narrative review examines how melatonin preserves and enhances female fertility by analyzing clinical outcomes and molecular pathways. It compiles research on the effects of melatonin on ovarian function, oocyte quality, hormone regulation, and assisted reproductive technologies from major databases published between 2015 and 2025. The study consistently shows how melatonin works and its potential benefits, offering broad insights without strict limits.</p> <p><strong>Result: </strong>Melatonin operates through multiple receptor-mediated pathways to regulate reproductive functions. Clinical evidence shows melatonin supplementation improves assisted reproductive technology (ART)’s success rates by enhancing oocyte maturation and embryo quality, restoring menstrual regularity in PCOS patients, and protecting reproductive tissues from oxidative stress-induced damage.</p> <p><strong>Implication:</strong> These findings support melatonin's therapeutic potential in assisted reproductive technologies and treating reproductive disorders. Healthcare providers should consider melatonin supplementation as an adjuvant therapy for women undergoing fertility treatments or experiencing reproductive dysfunction while establishing standardized protocols for optimal dosing and timing.</p> <p><strong>Novelty: </strong>This comprehensive review reveals melatonin's multifaceted role as a fertility regulator, providing molecular insights into its therapeutic mechanisms and clinical applications in women's reproductive health across the reproductive lifespan</p> Benedikta Diah Saraswati Copyright (c) 2025 Benedikta Diah Saraswati https://creativecommons.org/licenses/by-sa/4.0 2025-08-28 2025-08-28 5 1 1 14 10.53088/griyawidya.v5i1.1886