Griya Widya: Journal of Sexual and Reproductive Health

Melatonin’s Role in Female Fertility: Molecular Insights and Therapeutic Implications

Benedikta Diah Saraswati — 2025-08-28

Background: This narrative review examines how melatonin enhances reproductive health functions. Melatonin has established itself as a multifaceted neurohormone with pivotal roles in female reproductive health. Through its potent antioxidant properties, melatonin protects oocytes and orchestrates hormonal regulation and ovarian function, with melatonin receptors strategically located in key reproductive tissues, including ovarian granulosa and luteal cells.

Method: This narrative review examines how melatonin preserves and enhances female fertility by analyzing clinical outcomes and molecular pathways. It compiles research on the effects of melatonin on ovarian function, oocyte quality, hormone regulation, and assisted reproductive technologies from major databases published between 2015 and 2025. The study consistently shows how melatonin works and its potential benefits, offering broad insights without strict limits.

Result: Melatonin operates through multiple receptor-mediated pathways to regulate reproductive functions. Clinical evidence shows melatonin supplementation improves assisted reproductive technology (ART)’s success rates by enhancing oocyte maturation and embryo quality, restoring menstrual regularity in PCOS patients, and protecting reproductive tissues from oxidative stress-induced damage.

Implication: These findings support melatonin's therapeutic potential in assisted reproductive technologies and treating reproductive disorders. Healthcare providers should consider melatonin supplementation as an adjuvant therapy for women undergoing fertility treatments or experiencing reproductive dysfunction while establishing standardized protocols for optimal dosing and timing.

Novelty: This comprehensive review reveals melatonin's multifaceted role as a fertility regulator, providing molecular insights into its therapeutic mechanisms and clinical applications in women's reproductive health across the reproductive lifespan

Hubungan antara Prostatitis Kronis dan Gangguan Reproduksi Pria: Tinjauan Literatur Terkini

Abdul Hafiidh Surya Putra — 2025-09-04

Background: This literature review aims to present the latest scientific findings that explain the relationship between chronic prostatitis and male reproductive disorders.

Method: This study was a narrative literature review that identified articles from PubMed, Scopus, and Google Scholar using the keywords "chronic prostatitis", "CP/CPPS", "male infertility", "erectile dysfunction", and "ejaculatory dysfunction". Inclusion criteria include publications in the last 10 years that discuss the association between chronic prostatitis and male reproductive disorders. The data were analyzed descriptively to identify patterns of interdependence.

Results: Data synthesis showed that chronic prostatitis was associated with a significant decrease in sperm concentration, motility, morphology, and viability. Patients also had a threefold risk of erectile dysfunction, as well as a high prevalence of painful ejaculation (30–65%) and premature ejaculation (±40%). Inflammatory mechanisms and oxidative stress have been shown to play an important role in pathogenesis, while multimodal therapies, including antibiotics, antioxidants, PDE5 inhibitors, phytotherapy, and pelvic floor physiotherapy, show better effectiveness than monotherapy.

Implications: These results confirm the need to evaluate the reproductive aspect in patients with chronic prostatitis, as well as a multidisciplinary approach to improve quality of life and fertility.

Novelty: This study presents an up-to-date comprehensive review that integrates clinical evidence, pathophysiology, and therapeutic strategies, thereby enriching understanding and supporting the development of more effective management.

Pengaruh E-Flashcard pada Pengetahuan dan Sikap Remaja terkait Perilaku Seksual Berisiko

Tiari Dhiya Maharani — 2025-09-06

Background: Adolescence is a period marked by emotional instability, especially regarding sexual behavior. Curiosity about adult activities, such as sexual intercourse, often arises, and a lack of sexual education is a major factor contributing to risky sexual behavior. Educational tools such as e-flashcards, which provide materials and questions about sexual health, can be used to improve adolescent knowledge and attitudes.

Method: This study applied a quantitative approach with a quasi-experimental design using a non-equivalent control group. The experimental group was students from SMA Negeri Jatinangor, while the control group was from SMA Negeri 1 Majalaya. A total of 112 participants were selected using cluster random sampling. The instrument was a questionnaire adapted from Nadya (2022). Data were analyzed using the Mann-Whitney U Test.

Findings: Findings revealed that e-flashcards significantly improved knowledge. The Mann-Whitney test showed a mean rank difference of 17.42 with p = 0.003 (p < 0.05). For attitudes, the mean rank difference was 16.66 with p = 0.006 (p < 0.05). Although both groups improved, e-flashcards were more effective than PowerPoint.

Implication: E-flashcards effectively enhance adolescents’ knowledge and attitudes on risky sexual behaviors. Schools are encouraged to integrate this medium into health education programs

The Economics of Prostitution: How Does Prostitution Affect Family Resilience?

Risanda Budiantoro — 2025-09-11

Objective: This study aims to formulate an ideal government policy that addresses prostitution comprehensively.

Method: This study applies a qualitative descriptive-normative method. The data were obtained through secondary sources, document analysis, participatory and direct observations, as well as semi-structured interviews. Data analysis was conducted using an inductive approach through data reduction, classification, and interpretation. Triangulation methods were employed to ensure the validity and credibility of the data.

Result: The study reveals that the prostitution business in Indonesia is supported by complex networks involving pimps, sex workers, clients, and other indirect actors. The practice is driven by multiple factors including economic necessity, social vulnerability, low moral awareness, and inadequate family resilience. Additionally, prostitution has created both positive and negative externalities in the surrounding communities, especially in urban areas.

Implication: This study suggests that government policies must be integrative, addressing not only the legal aspects but also offering economic empowerment programs, family resilience development, and moral education. The findings highlight the importance of collaboration between state institutions, religious leaders, and community organizations to reduce the dependence on prostitution as a means of livelihood.

Novelty: This research offers a comprehensive framework by linking the economic, religious, and sociological dimensions of prostitution. Unlike prior studies that focus on a single aspect, this study presents prostitution as a systemic issue within the informal economy that requires a multi-sectoral and ethically grounded policy response

Pendidikan Pranikah bagi Calon Pengantin dalam Upaya Mewujudkan Keluarga Sakinah

Hakimah Warits — 2025-09-12

Background: Premarital education is a form of education for couples who will marry with the aim of preparing couples to enter married life. The content of pre-marital education is in the form of information, knowledge and basic skills training related to aspects that are expected to strengthen the relationship of the couple in order to be able to maintain married life. And the purpose of this study is to find out how education before entering the marriage stage is through a premarital marriage guidance program for brides and grooms at the Office of the Ministry of Religion, Sukoharjo.

Method: This research method itself is through a description with a qualitative approach. For data analysis using logical thinking, where a syllogism is built based on specific things and leads to general conclusions.

Result: The premarital marriage guidance program for prospective brides is divided into two formats, namely: face-to-face guidance and independent guidance. The success of premarital marriage guidance for prospective brides cannot be separated from supporting factors, namely: Regency Ministry of Religion as the organizing agency, budget legitimized sources of funds, prospective brides who become participants, quality resource persons, appropriate materials, and adequate facilities. The obstacles, both limited funds, places, facilities and learning media.

Implication: The Binwin facilitator in providing pre-marital guidance in an effort to create a sakinah family for the bride and groom.

Novelty: The premarital marriage guidance program for prospective brides is divided into two formats, namely: face-to-face guidance and independent guidance